Greetings - Casual Style

Conversation 1

A: Hey Joe, what's up?
B: Nothing much. How are things with you?
A: Not bad. Can't complain.
B: How's your job?
A: Ah, the same ole' same ole'. How are things at yours?
B: Ah, you don't want to know.

Conversation 2

A: So, how's life?
B: Good thanks. What's going on with you?
A: You know, the same routine.
B: How's your family?
A: Good and yours?
B: Could be better, could be worse.

Conversation 3

A: Hey Sue, what's new with you?
B: Nothing much. How about yourself?
A: Can't complain.
B: How are things with your girlfriend?
A: We broke up.
B: Oh, I'm sorry to hear that.
A: No worries. Life goes on.

Notes

Greetings with 'What ...?'

What's up?
What's going on?
What's happing?
What's new?
What's shaking? (slang)

Answers to 'What ---?'

Nothing much
Nada mucho
Not a whole lot.

Greetings with 'How ...?'

How's life?
How are things?
How are you doing?
How is your ( job / family / girlfriend )?

Answers to 'How---?'

Great
Good
Not bad

So-so
Can't complain
Could be better, could be worse
The same ole' same ole'

Bad
You don't want to know
Don't ask

Response to a bad answer
I am sorry to hear that